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Our results are in line with the study of Valena et al (45), in which rats receiving nicotine intraperitoneally had disorganised parenchyma and inflammatory cells infiltration

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Firstly, the CHRNB2 associations were based on European ancestry from the UKB (the main rare variant driving the CHRNB2 association occurs only in Europeans) and the CHRNB3 associations were based on Indigenous Mexican ancestry from the MCPS (the main rare variant driving the CHRNB3 association occurs only in Indigenous Mexicans)

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